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Cushing's Syndrome Pathophysiology
Cushing's Assessment, Signs & Symptoms
Cushing's Interventions & Treatment
Cushing's Patient & Family Teaching
Addison's Disease Pathophysiology
Addison's Assessment, Signs & Symptoms
Addison's Interventions & Treatment
Addison's Patient & Family Teaching
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Cushing's Syndrome Diagnosis and Diagnostic Tests
Comprehensive health history and physical examination
24 hour urine collection to assess for free cortisol
50-100 mcg/day of cortisol in urine indicates Cushing's syndrome (Lewis et al., 2007)
Levels may be elevated with loss of variation in absence of stress and illness
Dexamethasone suppression test (if urine tests are borderline)
Plasma ACTH levels
Can vary depending on underlying conditions
Normal to high levels indicate ACTH-dependent Cushing's disease (Pagana & Pagana, 2010)
Adrenal cortex disorders or use of medications can result in a decreased ACTH (ATI, 2010)
X-Ray, CT, MRI of pituitary gland, adrenal gland, lungs, GI tract, or pancreas to assess for lesions, tumors, or adrenal atrophy (ATI, 2010)
Hypokalemia, hypocalcemia, hypernatremia
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